About ChiSquare Bioimaging

ChiSquare Bioimaging LLC is a research and technology development company with expertise in enabling fluorescence imaging technology and spectroscopy for pre-clinical life science research. We focus on, but are not limited to, applications in neuroscience and breast cancer biology. As its name (ˌkaɪ ˈskweə) suggests, the company is built on the belief that scientific objectivity provides clarity to our scientific understanding and moves science and technology forward on solid ground.

ChiSquare scientists have carried out scientific work at the Max Planck Institute, Harvard Medical School, Cornell University, and Howard Hughes Medical Institute, with cross disciplinary knowledge spanning biochemistry, biophysics, spectroscopy, imaging microscopy, to plant and mammalian cell biology, and cancer biology. ChiSquare is supported in part by the Small Business Innovation Research program from the National Institutes of Health.

About Founder & Managing Director

Before founding ChiSquare Bioimaging, Loling Song was on the research faculty at Harvard Medical School (HMS), where her scientific focus was on using photophysical and quantitative fluorescence analyses to understand cellular energy metabolism and redox regulation in the context of cancer biology. Loling immersed herself in cell and molecular biological methods, redox biochemistry, and functionalized fluorescent protein-based sensors. She set up a live cell imaging system capable of two-photon excited fluorescence lifetime measurement using time-correlated single photon counting technology.

Loling's doctoral research at Leiden University elucidated the role of the triplet-excited state in photobleaching mechanisms, a long-standing issue in quantitative fluorescence microscopy. For her post-doctoral research at the Max Planck Institute for Biophysical Chemistry, with Thomas Jovin, Loling developed and characterized a novel method in which a photochromic molecule was used as a molecular light-driven switch to modulate Förster resonance energy transfer. Returning to the US, she carried out research with Watt W. Webb at Cornell University, before becoming a member of the research faculty at HMS.